Objective and Impact Statement. There is a need to develop platforms delineating inflammatory biology of the distal human lung. We describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal human lung using a combination of matrix metalloproteinase (MMP) optical reporters. fibered confocal fluorescence microscopy (FCFM). https://www.macorners.shop/product-category/clear-glass-cup/