Topoisomerase II is critical for DNA replication. transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including the anthracyclines and epipodophyllotoxins. However. these drugs are limited by common tumor resistance mechanisms and side-effect profiles. https://bbmbatteryes.shop/product-category/118/
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.
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