Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained. Herein. we report the efficient application of this approach to the synthesis of acylhydrazines bearing 1. https://goodvibesbadhabiters.shop/product-category/tom-of-finland/