We have developed a novel structure-based evaluation for missense variants that explicitly models protein structure and amino acid properties to predict the likelihood that a variant disrupts protein function. A structural disruption score (SDS) is introduced as a measure to depict the likelihood that a case variant is functional. The score is constructed using characteristics that di... https://www.jmannino.com/limited-offer-Disney-Mickey-Mouse-Pattern-Formation-Galaxy-A14-5G-Clear-Case-p103475-top-grab/